Oregon State University, College of Pharmacy, PhD in Medicinal Chemistry
Delaware Valley College, BS in Biology, Minor in Chemistry
Organic Chemistry I (CHM301)
Organic Chemistry II (CHM302)
Medicinal Chemistry (CHM490)
General Inorganic Chemistry (CHM101)
General Chemistry (CHM103)
Independent Research in Chemistry
Junior Seminar (NSM307)
Senior Seminar I (NSM497)
Freshman Gateway Seminar (GWS-101)
Wang, Y., Xu, H., Grochowski, L. L. & White, R. H. Biochemical characterization of a
dihydroneopterin aldolase used for methanopterin biosynthesis in methanogens. J. Bacteriol. 196, 3191–8 (2014).
de Crécy-Lagard V, Phillips G, Grochowski LL, El Yacoubi B, Jenney F, Adams MWW,
Murzin AG, and White, RH. (2012) Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of methanopterin and tetrahydrofolate. ACS Chemical Biology: 7(11) 1807-1816.
Grochowski LL, Censky K, Xu H, White RH. (2012) A new class of adenylate kinase in
methanogens is related to uridylate kinase. Arch Microbiol.;194(2):141-5.
Phillips G, Grochowski LL, Bonnett S, Xu H, Bailly M, Blaby-Haas C, El Yacoubi B,
Iwata-Reuyl D, White RH, de Crécy-Lagard V. (2012) Functional Promiscuity of the COG0720 Family. ACS Chem Biol. 2012 Jan 20;7(1):197-209.
Mashhadi, Z., Xu, H., Grochowski, L. L., and White, R. H. (2010). “Archaeal RibL: A New FAD Synthetase That Is Air Sensitive.” Biochemistry, 49(40), 8748-55.
Grochowski, L. L., and White, R. H. (2010) Biosynthesis of the Methanogenic Coenzymes, In Comprehensive Natural Products Chemistry II (Begley, T., Ed.), pp 711-748, Elsevier.
Grochowski, L. L., Xu, H., and White, R. H. (2009) An iron(II) dependent formamide hydrolase catalyzes the second step in the archaeal biosynthetic pathway to riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin, Biochemistry 48, 4181-4188.
Grochowski, L. L., Xu, H., and White, R. H. (2008) Identification and characterization of the 2-phospho-L-lactate guanylyltransferase involved in coenzyme F420 biosynthesis, Biochemistry 47, 3033-3037.
Forouhar, F., Abashidze, M., Xu, H., Grochowski, L. L., Seetharaman, J., Hussain, M., Kuzin, A., Chen, Y., Zhou, W., Xiao, R., Acton, T. B., Montelione, G. T., Galinier, A., White, R. H., and Tong, L. (2008) Molecular insights into the biosynthesis of the F420 coenzyme, J. Biol. Chem. 283, 11832-11840.
Grochowski, L. L., and White, R. H. (2008) Promiscuous anaerobes: new and unconventional metabolism in methanogenic archaea, Ann. N Y Acad. Sci. 1125, 190-214
Nocek, B., Evdokimova, E., Proudfoot, M., Kudritska, M., Grochowski, L. L., White, R. H., Savchenko, A., Yakunin, A. F., Edwards, A., and Joachimiak, A. (2007) Structure of an Amide Bond Forming F(420):gammagamma-glutamyl Ligase from Archaeoglobus Fulgidus – A Member of a New Family of Non-ribosomal Peptide Synthases, J Mol Biol. In Press
Grochowski, L. L., Xu, H., Leung, K., and White, R. H. (2007) Characterization of an Fe(2+)-Dependent Archaeal-Specific GTP Cyclohydrolase, MptA, from Methanocaldococcus jannaschii, Biochemistry 46, 6658-6667.
Grochowski, L. L., Xu, H., and White, R. H. (2006) Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate, J. Bacteriol. 188, 3192-3198.
Grochowski, L. L., Xu, H., and White, R. H. (2006) Identification of lactaldehyde dehydrogenase in Methanocaldococcus jannaschii and its involvement in production of lactate for F420 biosynthesis, J. Bacteriol. 188, 2836-2844.
Grochowski, L. L., and Zabriskie, T. M. (2006) Characterization of BlsM, a nucleotide hydrolase involved in cytosine production for the biosynthesis of blasticidin S, Chembiochem 7, 957-964.
Grochowski, L. L., Xu, H., and White, R. H. (2005) Ribose-5-phosphate biosynthesis in Methanocaldococcus jannaschii occurs in the absence of a pentose-phosphate pathway, J. Bacteriol. 187, 7382-7389.
Cone, M. C., Yin, X., Grochowski, L. L., Parker, M. R., and Zabriskie, T. M. (2003) The blasticidin S biosynthesis gene cluster from Streptomyces griseochromogenes: sequence analysis, organization, and initial characterization, Chembiochem 4, 821-828.
Schnable, J. G., Grochowski, P. J., Wilhelm, L., Harding, C., Kiefer, M., and Orr, R. S. (1998) Portable LED-array VIS-NIR spectrophotometer/nephelometer, Field Analytical Chemistry and Technology 2, 21-28. (Published as Laura Wilhelm).
1. Yin, X.; Mahadevan, B., Grochowski, L.; and Proteau, P.J. Streptomyces murayamaensis kinamycin gene cluster, partial sequence (34,564 bp). Direct submission to GenBank. (Accession #AY228175).
2. Yin, X.; Mahadevan, B., Grochowski, L.; and Proteau, P.J. Streptomyces murayamaensis putative ribonucleotide reductase gene, partial CDS adjacent to the kinamycin gene cluster (2563 bp). Direct submission to GenBank. (Accession #AY228174).
3. Cone, MC.; Grochowski, L.; Yin, X.; and Zabriskie T.M. Complete Sequence and Organization of the Blasticidin S Biosynthesis Gene Cluster from Streptomyces griseochromogenes (36,677 bp). Direct submission to GenBank, (Accession #AY196214).
Although my main research interests are in the study of antibiotic and coenzyme biosynthesis, I enjoy working with students to explore areas of chemistry in which they are most interested. Past student projects have involved isolation of natural products from plant sources and the induction of secondary metabolites following plant infestation with root-knot nematodes. Other research projects I have mentored have allowed students to become more familiar with the instrumentation that we have available. This has included the development of a new lab for Environmental Science focused on the detection of polyaromatic compounds in soil following industrial contamination by GC-MS and the analysis of blood alcohol content by GC-MS.